Sertaconazole interacts with 14-α-demethylase, a cytochrome P-450 enzyme required for the conversion of lanosterol to ergosterol.
As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability, causing leakage of cellular contents.
Sertaconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts into mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
⚠️ Warnings
Pregnancy
Pregnancy:
A risk/benefit assessment should be made before use during pregnancy.
Breastfeeding
Breastfeeding:
A risk/benefit assessment should be made before use during breastfeeding.
If no improvement occurs within 2 weeks or if the condition worsens, contact a physician for further instructions.
Excessive use of topical products may worsen the condition.
Do not use sertaconazole for any condition other than that for which it was prescribed.
Sertaconazole is not recommended for use in children under 12 years of age.
Safety and efficacy in this age group have not been established.
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