UGARON CAPSULE

1IVO,1JL9,1NQL,1P9J,2KV4,3NJP renal medullabody of pancreasmuscle of thighhuman kidneykidney tubulegastrocnemius muscleSkeletal muscle tissue of rectus abdominisbiceps brachiideltoid musclevastus lateralis muscle submandibular glandhuman kidneyright kidneyparotid glandvestibular membrane of cochlear ductprostatelobe of prostateextensor digitorum longus muscleplantaris musclevastus lateralis muscle calcium ion bindingtransmembrane receptor protein tyrosine kinase activator activityepidermal growth factor receptor bindingWnt-protein bindingprotein bindinggrowth factor activityWnt-activated receptor activityprotein tyrosine kinase activityphosphatidylinositol-4,5-bisphosphate 3-kinase activity integral component of membranemembranereceptor complexextracellular regionlysosomal membraneextracellular exosomeplatelet alpha granule lumenextracellular spaceclathrin-coated vesicle membraneplasma membrane negative regulation of epidermal growth factor receptor signaling pathwaypositive regulation of MAP kinase activityepidermal growth factor receptor signaling pathwayregulation of protein localization to cell surfaceERK1 and ERK2 cascadeplatelet degranulationregulation of calcium ion importmammary gland alveolus developmentMAPK cascadeDNA replicationpositive regulation of transcription, DNA-templatednegative regulation of secretionpositive regulation of hyaluronan biosynthetic processpositive regulation of peptidyl-threonine phosphorylationpositive regulation of ubiquitin-dependent protein catabolic processangiogenesisWnt signaling pathway involved in dorsal/ventral axis specificationpositive regulation of cell population proliferationpositive regulation of peptidyl-tyrosine phosphorylationpositive regulation of cerebellar granule cell precursor proliferationcanonical Wnt signaling pathwaynegative regulation of cholesterol effluxpeptidyl-tyrosine phosphorylationpositive regulation of DNA bindingpositive regulation of phosphorylationpositive regulation of mitotic nuclear divisionbranching morphogenesis of an epithelial tubesignal transductionregulation of peptidyl-tyrosine phosphorylationERBB2 signaling pathwayphosphatidylinositol phosphate biosynthetic processpositive regulation of protein tyrosine kinase activityactivation of transmembrane receptor protein tyrosine kinase activityregulation of cell motilitypositive regulation of receptor internalizationpositive regulation of epidermal growth factor-activated receptor activitymembrane organizationnegative regulation of ERBB signaling pathwayembryonic retina morphogenesis in camera-type eyepositive regulation of gene expressionpositive regulation of cell migrationpositive regulation of protein kinase B signalingnegative regulation of Notch signaling pathwayregulation of receptor signaling pathway via JAK-STATpositive regulation of canonical Wnt signaling pathwaypositive regulation of protein localization to early endosome 1950 13645 ENSG00000138798 ENSMUSG00000028017 P01133 P01132 NM_001178130NM_001178131NM_001963NM_001357021 NM_010113NM_001310737NM_001329594 NP_001171601NP_001171602NP_001954NP_001343950 NP_001297666NP_001316523NP_034243 Epidermal growth factor(EGF) is aproteinthat stimulatescell growthanddifferentiationby binding to its receptor,EGFR.HumanEGF is 6-kDaand has 53amino acid residuesand three intramoleculardisulfide bonds. EGF was originally described as a secreted peptide found in thesubmaxillary glandsofmiceand in humanurine. EGF has since been found in many human tissues, includingplatelets,submandibular gland(submaxillary gland),andparotid gland.Initially, human EGF was known asurogastrone.