CONDRODIN 400MG Hard capsule

Pharmacotherapeutic group: other non-steroidal anti-inflammatory and antirheumatic agents, ATC code: M01AX25 The active substance in Condrodin, chondroitin sulfate sodium salt, is a polysaccharide belonging to the glycosaminoglycan group. Chondroitin sulfate is one of the major components of cartilage, as it forms part of its main protein, proteoglycan, which is the basis for the mechanical and elastic properties of cartilage. The therapeutic ​​​‍​​‍​​​​‍​​‍‍effects of chondroitin sulfate in patients with osteoarthritis are based on an anti-inflammatory effect at the cellular level (in vivo), stimulation of endogenous proteoglycan synthesis (in vitro) and hyaluronic acid synthesis (in vivo), and reduction of the catabolic activity of chondrocytes (in vivo) by inhibiting certain proteolytic enzymes (e.g. collagenase, elastase, proteoglycanase, phospholipase A2, N-acetyl-glucosaminidase) (in vitro, in vivo) as well as formation of other substances damaging cartilage (in vitro). Clinical studies in patients with osteoarthritis have shown that treatment with chondroitin sulfate eliminates or improves osteoarthritis symptoms of the knees and hips, such as pain and functional limitation. The effect manifests within 6–8 weeks and persists for 2–3 months after completion of treatment. For short-term pain relief, diclofenac has superior efficacy.