TILADE CFC-FREE INHALER

R01AC07(WHO)R03BC03(WHO),S01GX04(WHO) AU:S4(Prescription only)UK:POM(Prescription only)US:℞-only 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid 69049-73-6Y 50294 7607 DB00716Y 45608Y 0B535E0BN0 D05129Y CHEBI:7492Y ChEMBL746Y DTXSID7023356 Interactive image O=C\1c3c(N(/C(C(=O)O)=C/1)CC)c(c2O/C(=C\C(=O)c2c3)C(=O)O)CCC InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)YKey:RQTOOFIXOKYGAN-UHFFFAOYSA-NY Nedocromil sodiumis amedicationconsidered amast cell stabilizerwhich acts to prevent wheezing, shortness of breath, and other breathing problems caused byasthma.‍‍‍‍‍‍​​​‍​​​​​​ It is administered by aninhalerunder the brand nameTilade, and as aneye dropunder the brand nameAlocril.The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators likealbuterolor other well-knowninhalermedications. Liquid preparations of nedocromil are available in theUKunder the nameRapitilfor use for allergic eye reactions.Nedocromil sodium has been shown to be effective in alleviating symptoms ofallergic conjunctivitis. Nedocromil is classified as abenzopyrone. Nedocromil acts as amast cell stabilizer, inhibits the degranulation ofmast cells, prevents release ofhistamineandtryptase, so preventing the synthesis ofprostaglandinsandleukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it usedCFCsas propellant.