What is SYNAREL NASAL SOLUTION used for?

Nafarelin is approved and used in the treatment ofendometriosisandprecocious puberty.It is also used in the treatment ofuterine fibroids.The medication is used tocontrol ovarian stimulationinin vitrofertilization(IVF).Nafarelin is used as apuberty blockerintransgender youthand to suppresstestosteronelevels intransgender women.Nafarelin can also be used to treathirsutismandpolycystic ovary syndromeby loweringgonadotropinandandrogenlevels.It is effective in the treatment ofbenign

What pharmaceutical form is SYNAREL NASAL SOLUTION available in?

SYNAREL NASAL SOLUTION: 鼻用噴液劑

What are the side effects of SYNAREL NASAL SOLUTION?

Side effectsof nafarelin are related tosex hormone deficiencyand includehot flashes,vaginal dryness,headaches,mood changes, andsexual dysfunction. Nafarelin causeserectile dysfunctionin more than half of men withbenign prostatic hyperplasiatreated with it.Some people may experienceacne,muscle pain,reduced breast size, andnasal irritation. These side effects are reversible and should resolve after stopping the medication.There is acase reportof severehyperkalemiaduring nafarelin

Can SYNAREL NASAL SOLUTION be used during pregnancy?

( AHT ) For the active ingredient nafarelin You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

What precautions should be taken with SYNAREL NASAL SOLUTION?

• Do not use in patients with risk factors for decreased bone mineral density. Ovarian cysts may occur during the first 2 month of therapy, more commonly in women with polycystic ovarian disease. Monitor patient regularly, especially during the first 6-8 week of therapy to ensure patient compliance and adequate response. Determine bone age and growth velocity within 3-6 month of initiation of therapy and periodically thereafter.

Who manufactures SYNAREL NASAL SOLUTION?

PFIZER PHARMACEUTICALS LLC (CAGUAS PLANT) (TW)

What ATC class does SYNAREL NASAL SOLUTION belong to?

SYNAREL NASAL SOLUTION: ATC H01CA02. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

SYNAREL NASAL SOLUTION

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

X H01CA02(WHO) In general: ℞ (Prescription only) (2R)-N-[(2R)-5-carbamimidamido-1-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-2-[(2R)-2-[(2R)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-4-yl)-2-{[(2R)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]-3-(naphthalen-2-yl)propanamido]-4-methylpentanamide 76932-56-4Y76932-60-0 (acetate) 25077649 3902 DB00666Y 10482014Y 1X0094V6JV D08241 CHEBI:7445Y ChEMBL1201309Y DTXSID001031284 Interactive image CC(C)C[C@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O InChI=1S/C66H83N17O13/c1-36(2)25-48(58(89)76-47(13-7-23-71-66(68)69)65(96)83‍‍‍‍‍‍‍‍-24-8-14-54(83)64(95)73-33-55(67)86)77-60(91)50(28-38-15-18-39-9-3-4-10-40(39)26-38)78-59(90)49(27-37-16-19-43(85)20-17-37)79-63(94)53(34-84)82-61(92)51(29-41-31-72-45-12-6-5-11-44(41)45)80-62(93)52(30-42-32-70-35-74-42)81-57(88)46-21-22-56(87)75-46/h3-6,9-12,15-20,26,31-32,35-36,46-54,72,84-85H,7-8,13-14,21-25,27-30,33-34H2,1-2H3,(H2,67,86)(H,70,74)(H,73,95)(H,75,87)(H,76,89)(H,77,91)(H,78,90)(H,79,94)(H,80,93)(H,81,88)(H,82,92)(H4,68,69,71)/t46-,47-,48-,49-,50+,51-,52-,53-,54-/m0/s1YKey:RWHUEXWOYVBUCI-ITQXDASVSA-NY Nafarelin, sold under the brand nameSynarelamong others, is agonadotropin-releasing hormone agonist(GnRH agonist) medication which is used in the treatment ofendometriosisandearly puberty.It is also used to treatuterine fibroids, tocontrol ovarian stimulationinin vitrofertilization(IVF), and as part oftransgender hormone therapy.The medication is used as anasal spraytwo to three times per day. Side effectsof nafarelin are related tosex hormonedeprivationand includesymptomsoflow testosterone levelsandlow estrogen levelssuch ashot flashes,sexual dysfunction,vaginal atrophy, andosteoporosis.Nafarelin is agonadotropin-releasing hormone agonist(GnRH agonist) and works by preventing theproductionofsex hormonesby thegonads.It can lower sex hormone levels by 95% in both sexes.Nafarelin is apeptideand ananalogueofGnRHTooltip gonadotropin-releasing hormone. Nafarelin was introduced for medical use in 1990.It is available widely throughout the world, including inNorth America,Europe, and elsewhere throughout the world.The medication is one of only two medically used GnRH analogues that are available as nasal sprays, the other beingbuserelin.

SYNAREL NASAL SOLUTION

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