F.E.V. 300

85-61-0(free acid)Y55672-92-9(sodium salt hydrate)N18439-24-2(lithium salt)N Interactive image CHEBI:15346N ChEMBL1213327N 6557Y DB01992Y C00010Y 6816 SAA04E81UXY InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16?,20-/m1/s1YKey: RGJOEKWQDUBAIZ-DRCCLKDXSA-NYInChI=1/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6‍‍‍‍‍‍​​​‍​​​​​​-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16?,20-/m1/s1Key: RGJOEKWQDUBAIZ-DRCCLKDXBU O=C(NCCS)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3OP(=O)(O)O Coenzyme A(CoA,SHCoA,CoASH) is acoenzyme, notable for its role in thesynthesisandoxidationoffatty acids, and the oxidation ofpyruvatein thecitric acid cycle. Everygenomesequenced to date encodes enzymes that use coenzyme A as asubstrate, and around 4% of cellular enzymes use it (or athioester) as a substrate. In humans, CoA biosynthesis requirescysteine,pantothenate(vitamin B5), andadenosine triphosphate(ATP). Inits acetyl form, coenzyme A is a highly versatile molecule, serving metabolic functions in both theanabolicandcatabolicpathways. Acetyl-CoA is utilised in thepost-translational regulationandallosteric regulationofpyruvate dehydrogenaseandcarboxylaseto maintain and support the partition ofpyruvatesynthesis and degradation.