ALLOFERIN AMPOULES 10MG/2ML

M03AA01(WHO) 4,4'-Didemethyl-4,4'-di-propenyltoxiferin-1-dichloride 15180-03-7N 5311001 341 20118193Y 490DW6501Y CHEBI:31185Y DTXSID0045414 Interactive image [Cl-].[Cl-].OC\C=C6\C[N@+]4(CC=C)CC[C@@]58c%11ccccc%11N7\C=C9\[C@H]1C[C@H]2[C@@]%10(CC[N@@+]2(CC=C)C\C1=C\CO)c3ccccc3N(/C=C(/[C@H]6C[C@H]45)[C@H]78)[C@@H]9%10 InChI=1S/C44H50N4O2.2ClH/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49;;/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2;2*1H/q+2;;/p-2/b29-13-,30-14-,33-25-,34-26-;;/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-;;/m0../s1YKey:CPYGBGOXCJJJGC-GKLGUMFISA-LY Alcuronium chloride(formerly marketed asAlloferin) is aneuromuscular blocking (NMB) agent, alternatively referred to as a skeletalmuscle relaxant.​​​‍​​‍​​​​‍​​‍‍ It is a semi-synthetic substance prepared from C-toxiferineI,abis-quaternary alkaloid obtained fromStrychnos toxifera. C-toxiferineI itself has been tested for its pharmacological action and noted to be a very long acting neuromuscular blocking agentFor a formal definition of the durations of actions associated with NMB agents, see page forgantacurium. The replacement of both theN-methyl groups withN-allylmoieties yieldedN,N-diallyl-bis-nortoxiferine, now recognized as alcuronium. Inclusion of the allylic functions presented an enhanced potential area of biotransformation, and thus alcuronium is observed to have a much shorter duration of neuromuscular blocking action than its parent C-toxiferine I.It also has a more rapid onset of action, and is ~1.5 times as potent astubocurarine.The pharmacological action of alcuronium is readily reversed byneostigmine, and it produces littlehistaminerelease.The major disadvantage of alcuronium is that it elicits a vagolytic effect produced by a selectiveatropine-like blockade of cardiacmuscarinic receptors.