HALIBUT LIVER OIL CAPSULES 6,000/1,000I.U. VITAMIN A/D

1BWX,1ET1,1FVY,1HPH,1HPY,1HTH,1ZWA,1ZWB,1ZWD,1ZWE,1ZWF,1ZWG,2L1X,3C4M testicleretinal pigment epitheliummuscle tissuebody of stomachfundusembryofallopian tubesmooth muscle tissueganglionic eminencemammary gland tracheaparathyroidesophagussuperior colliculusmedulla oblongatapancreassubmandibular glandmorulathymusgastrula transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindinghormone activityparathyroid hormone receptor bindingtype 1 parathyroid hormone receptor bindingprotein N-terminus bindingreceptor ligand activitypeptide hormone receptor bindingDNA-binding transcription factor activity, RNA polymerase II-specificprotein binding intracellular anatomical structureextracellular regionextracellular space positive regulation of signal transductionpositive regulation of cell proliferation in bone marrowpositive regulation of osteoclast proliferationresponse to fibroblast growth factorhormone-mediated apoptotic signaling pathwaycAMP metabolic processresponse to ethanolresponse to parathyroid hormoneskeletal system developmentpositive regulation of ossificationresponse to lead ionresponse to nutrient levelsG protein-coupled receptor signaling pathwayresponse to vitamin Dnegative regulation of apoptotic process in bone marrow cellnegative regulation of transcription by RNA polymerase IIcellular macromolecule biosynthetic processcellular calcium ion homeostasishomeostasis of number of cells within a tissueresponse to cadmium ionRho protein signal transductionpositive regulation of glucose importpositive regulation of glycogen biosynthetic processbone resorptionpositive regulation of bone mineralizationregulation of gene expressionpositive regulation of transcription by RNA polymerase IIcell-cell signalingactivation of phospholipase C activitynegative regulation of chondrocyte differentiationpositive regulation of inositol phosphate biosynthetic processnegative regulation of bone mineralization involved in bone maturationregulation of signaling receptor activityadenylate cyclase-activating G protein-coupled receptor signaling pathwaycalcium ion transportmagnesium ion homeostasisbone mineralizationphosphate ion homeostasiscalcium ion homeostasisnegative regulation of calcium ion transport 5741 19226 ENSG00000152266 ENSMUSG00000059077 P01270 Q9Z0L6 NM_000315NM_001316352 NM_020623 NP_000306NP_001303281 NP_065648 Parathyroid hormone(PTH), also known asparathormoneorparathyrin, is apeptide hormonesecreted by theparathyroid glands. It plays a critical role in regulatingserum calciumandphosphatelevels through its actions onbone,kidneys, and thesmall intestine. PTH increases serum calcium levels and is opposed bycalcitonin. It also promotes the synthesis ofcalcitriol, the active form ofvitamin D. PTH is secreted in response to low blood serumcalcium(Ca2+) levels and is a key regulator ofbone remodeling, the continuous process of bone resorption and formation. PTH indirectly stimulatesosteoclastactivity, promoting the release of calcium from thebone matrixto restore serum calcium levels. Thebonesserve as a reservoir of calcium, releasing it as needed to maintain homeostasis in the face of fluctuatingmetabolism,stress, andnutritionalstatus. Produced primarily by thechief cellsof the parathyroid glands, PTH is apolypeptideprohormone(precursor to a hormone) consisting of 84amino acidsand has a molecular mass of approximately 9500Da. Its gene is located onchromosome 11in humans. PTH exerts its biological effects via two main receptors. TheParathyroid hormone 1 receptor, activated by the 34 N-terminal amino acids of PTH, is highly expressed in bone and kidney cells. TheParathyroid hormone 2 receptoris predominantly found in thecentral nervous system,pancreas,testes, andplacenta.The hormone has a short half-life of approximately 4 minutes.Dysregulation of PTH secretion, as seen in conditions likehypoparathyroidism,hyperparathyroidism, andparaneoplastic syndromes, can result inbone disease,hypocalcemia, orhypercalcemia.