PIPO CREAM (EXTERNAL USE)

THF is a relatively acutely nontoxic solvent, with themedian lethal dose(LD50) comparable to that foracetone.​​​‍​​‍​​​​‍​​‍‍ However, chronic exposure is suspected of causing cancer.Reflecting its remarkable solvent properties, it penetrates the skin, causing rapid dehydration. It is highly flammable. THF dissolves or penetrates most polymer glove materials in a very short period of time; onlyLinear low-density polyethylene(LLDPE) laminated gloves are capable of protecting against it for long time periods, similar to most ketones.Polyvinyl alcohol(PVA) coated gloves are capable of providing protection for nearly an hour, but because PVA is water soluble they are only effective in low humidity environments and when working with anhydrous solvents.Even very thick nitrile or nitrile-neoprene gloves degrade in under 10 minutes. One danger posed by THF is its tendency to form the explosive compound 2-hydroperoxytetrahydrofuran upon reaction with air: To minimize this problem, commercial supplies of THF are often stabilized withbutylated hydroxytoluene(BHT). Distillation of THF to dryness is unsafe because the explosive peroxides can concentrate in the residue.