Perazine

Pregnancy Pregnancy: The medicinal product must not be administered to pregnant women. Renal Impairment Renal Impairment: Do not administer in renal impairment. Hepatic Impairment Hepatic Impairment: Do not administer in hepatic impairment. Driving Driving: Sedative effects are most pronounced during the first days of treatment; affected patients should not drive or operate machinery. It should be used with caution or not at all in patients with hepatic, renal, cardiovascular, cerebrovascular, or respiratory insufficiency, and in those with angle-closure glaucoma, history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention. Caution is required in patients with epilepsy or a history of seizures, as phenothiazines may lower the seizure threshold. Debilitated patients may be more susceptible to the adverse effects of phenothiazines, as may the elderly, particularly those with dementia. Sedative effects are most pronounced during the first days of treatment; affected patients should not drive or operate machinery. Effects on the vomiting centre may mask the symptoms of overdose of other medicinal products or of disorders such as gastrointestinal obstruction. Use in extreme temperatures may be hazardous, as body temperature regulation is impaired by phenothiazines. It should be used with caution in the presence of acute infection or leucopenia. A blood count is recommended if the patient develops an unexplained infection or fever.