The exact mechanism of anti-inflammatory activity of topical steroids used in the treatment of steroid-responsive dermatoses is generally uncertain.
However, corticosteroids are formulated to act by inducing phospholipase A2 inhibitory proteins, collectively called lipocortins.
It is postulated that these proteins control the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid.
Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Initially, however, clobetasol, like other corticosteroids, binds to the glucocorticoid receptor, which forms complexes, enters the cell nucleus, and modifies gene transcription (transrepression/transactivation).
⚠️ Warnings
Pregnancy
Pregnancy:
Administration of clobetasol during pregnancy should only be considered if the expected benefit to the mother outweighs the risk to the foetus. The minimum amount should be used for the shortest period of time.
Breastfeeding
Breastfeeding:
The use of this medicine during breastfeeding is not recommended.
It is very important that the doctor checks progress at regular visits, to monitor for any undesirable effects that may be caused by clobetasol.
If symptoms do not improve within a few days, or if they worsen, consult your doctor.
Excessive use of clobetasol or use over a long period may increase the risk of adrenal gland problems. The risk is higher for children and patients who use large amounts over a long time.
Talk to your doctor immediately if you experience more than one of these symptoms while using clobetasol: blurred vision, dizziness or fainting, rapid or irregular heartbeat, increased thirst or urination, irritability, tiredness or weakness.
Talk to your doctor immediately if you have a skin allergy, burning, stinging, swelling, or skin irritation.
Make sure the doctor knows you are using clobetasol cream or gel. You may need to stop using clobetasol several days before surgery.
Do not use clobetasol together with other medicines containing topical corticosteroids, such as betamethasone, hydrocortisone, or triamcinolone. Using these medicines together may cause serious adverse effects.
Do not use cosmetics or other skin care products on the treated areas.
