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( ARTG ) Anaerobic infections: Suppositories Treatment of anaerobic infection in patients for whom oral medication is not possible or is contraindicated.​‍​​​​​‍​‍‍‍‍​‍‍ Prevention of anaerobic infection in high risk situations in patients for whom oral medication is not possible or is contraindicated. Metronidazole may be used prophylactically to prevent infection of the surgical site which may have been contaminated or potentially contaminated with anaerobic organisms. Procedures in which this may be assumed to have happened include appendicectomy, colonic surgery, vaginal hysterectomy, abdominal surgery in the presence of anaerobes in the peritoneal cavity and surgery performed in the presence of anaerobic septicaemia. Note. Metronidazole is inactive against aerobic and facultative anaerobic bacteria.