In various experimental models, it has been demonstrated that the triterpenoid glycoside mixture aescin, the principal constituent of the dry extract of horse chestnut seeds, has anti-exudative and capillary-sealing properties.
It has been observed that horse chestnut seed extract reduces the activity of lysosomal enzymes, whose activity is increased in chronic venous disease, thereby inhibiting the breakdown of glycocalyx (mucopolysaccharides) in the capillary wall.
By reducing vascular permeability, the filtration of low molecular weight proteins, electrolytes, and water into the interstitial space is prevented.
In placebo-controlled pharmacological studies in humans, a significant reduction in transcapillary filtration has been demonstrated, and in several double-blind, randomised or crossover studies, a significant improvement in the symptoms of chronic venous insufficiency (sensation of tiredness, heaviness and tension, pruritus, leg pain and oedema) has been shown.
⚠️ Warnings
Pregnancy
Pregnancy:
Administration during pregnancy is not recommended.
Breast-feeding
Breast-feeding:
Administration during breast-feeding is not recommended.
All other non-invasive measures recommended by the physician should always be followed, such as leg bandaging, use of compression stockings, or application of cold water showers to the legs.
In the event of sudden worsening of symptoms, especially if affecting only one leg, characterised by swelling, skin discolouration, a sensation of tension or warmth, as well as pain, it is recommended to consult a physician immediately, as these signs may be symptoms of a serious condition (deep vein thrombosis).
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