Daktarin

Miconazole is an antifungal agent belonging to the azole class, used for the treatment of fungal infections. Its effects are based on the inhibition of ergosterol synthesis through inhibition of the enzyme lanosterol 14α-demethylase in fungi. Miconazole is administered topically, usually twice daily. Possible adverse effects include local skin reactions such as burning, erythema, and irritation. Miconazole is an inhibitor of CYP450 isoenzymes. Miconazole (ATC D01AC02) has antifungal activity against dermatophytes, yeasts, moulds, and dimorphic fungi. It is also active against certain bacteria. Its effects are based on inhibition of the enzyme lanosterol 14α-demethylase in fungi. This inhibits the synthesis of ergosterol from lanosterol, leading to the accumulation of toxic precursors and disruption of fungal cell membrane assembly.