Miconazole is an antifungal agent belonging to the azole class, used for the treatment of fungal infections. Its activity is based on inhibition of ergosterol synthesis through blockade of the enzyme lanosterol 14α-demethylase in fungi. Miconazole is administered topically, typically twice daily. Possible adverse effects include local skin reactions such as burning, erythema, and irritation. Miconazole is an inhibitor of CYP450 isoenzymes.
Miconazole (ATC D01AC02) exhibits antifungal activity against dermatophytes, yeasts, molds, and dimorphic fungi. It is also active against certain bacteria. Its effects are mediated through inhibition of the enzyme lanosterol 14α-demethylase in fungi.
This blocks the synthesis of ergosterol from lanosterol, leading to the accumulation of toxic intermediates and disruption of fungal cell membrane formation.
