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USDailyMed:Amiodarone AU:C C01BD01(WHO) AU:S4(Prescription only)CA:℞-onlyUS:℞-only (2-(2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone 1951-25-3Y 2157 2566 DB01118Y 2072Y N3RQ532IUT D02910Y CHEBI:2663Y ChEMBL633Y DTXSID7022592 Interactive image CCN(CC)CCOc1c(I)cc(cc1I)C(=O)c2c3ccccc3oc2CCCC InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3YKey:IYIKLHRQXLHMJQ-UHFFFAOYSA-NY Amiodaroneis anantiarrhythmic medicationused to treat and prevent a number of types ofcardiac dysrhythmias.This includesventricular tachycardia,ventricular fibrillation, andwide complex tachycardia,atrial fibrillation, andparoxysmal supraventricular tachycardia.Evidence of benefit forcardiac arrestis poor.It can be given by mouth,intravenously, orintraosseously.When used by mouth, it can take a few weeks for effects to begin. Common side effects include feeling tired, tremor, nausea, and constipation.As amiodarone can have serious side effects, it is mainly recommended only for significant ventricular arrhythmias.Serious side effects include lung toxicitysuch asinterstitial pneumonitis,liver problems, heart arrhythmias, vision problems,thyroid problems, and death.If taken duringpregnancyorbreastfeedingit can cause problems in the fetus or the infant.It is aclass III antiarrhythmic medication.It works partly by increasing the time before a heart cell can contract again. Amiodarone was first made in 1961 and came into medical use in 1962 forchest pain believed to be related to the heart.It was pulled from the market in 1967 due to side effects.In 1974 it was found to be useful for arrhythmias and reintroduced.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the 218th most commonly prescribed medication in the United States, with more than 1million prescriptions.