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Gentamicin — Description, Dosage, Side Effects | PillsCard
OTC
Gentamicin
(0,64 mg + 1 mg)/g, Krem
INN: Betamethasoni dipropionas + Gentamicinum
Data updated: 2026-04-08
Available in:
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Form
Krem
Dosage
(0,64 mg + 1 mg)/g
Route
—
Storage
—
User Reviews
Reviews reflect personal experiences and are not medical advice. Always consult your doctor.
About This Product
Manufacturer
Aga Kommerz spol. s r.o.
ATC Code
D07CC01
Source
URPL
Pharmacotherapeutic group: Corticosteroids, potent, combinations with antibiotics — betamethasone and antibiotics; ATC code: D07CC01.
The cream contains betamethasone in the form of betamethasone dipropionate and gentamicin in the form of gentamicin sulfate.
Mechanism of action
Betamethasone is a synthetic, fluorinated corticosteroid for topical use in dermatology with potent anti-inflammatory, immunosuppressive and antiproliferative activity. It is a synthetic derivative of prednisolone that exhibits high corticosteroid activity and negligible mineralocorticoid effect.
The precise mechanism of action of topical corticosteroids is not fully understood; it is thought to involve a combination of anti-inflammatory, immunosuppressive and antiproliferative effects, of which the anti-inflammatory action is the most important. Corticosteroids inhibit the formation, release and activity of chemical mediators of inflammation (kinins, histamine, lysosomal enzymes, prostaglandins). They also inhibit the migration of leukocytes and macrophages — which are required at the very onset of the immune response — to the affected site, reduce vasodilation and decrease vascular permeability at the site of inflammation. This vasoconstrictive effect reduces serum extravasation and oedema formation. Corticosteroids also exert an immunosuppressive effect on type III and type IV hypersensitivity reactions by inhibiting the toxic activity of antigen-antibody complexes deposited in vessel walls that give rise to allergic cutaneous vasculitis, and by inhibiting the activity of lymphokines, target cells and macrophages, which together mediate allergic reactions such as allergic contact dermatitis. Corticosteroids also prevent sensitised T-lymphocytes and macrophages from reaching their target cells.
Gentamicin is an aminoglycoside antibiotic with marked bactericidal activity. It inhibits bacterial protein synthesis by binding to a specific receptor on the 30S subunit of the bacterial ribosome and interfering with the initiation complex of peptide formation. This causes misreading of the mRNA code, resulting in the production of non-functional proteins.
⚠️ Warnings
If an allergic reaction occurs during treatment, therapy must be discontinued immediately.
Areas treated with the cream should not be covered with an occlusive dressing unless strictly necessary. Local and systemic toxicity is common, particularly with long-term continuous use on extensive areas of broken skin, in flexures or under polyethylene occlusion. When used in children or on the face, treatment must be limited to 5 days. Long-term continuous treatment is undesirable in all patients regardless of age.
The cream must not be applied to the eyes or the periorbital region because of the risk of cataract, glaucoma, ocular mycotic infection and exacerbation of herpes simplex.
Certain body sites such as the groin, axillae and perianal region are more prone to the development of striae during treatment with Belogent. Application to these areas should therefore be kept as brief as possible.
Do not use to treat wounds or leg ulcers.
Systemic absorption of betamethasone dipropionate may cause reversible suppression of the hypothalamic-pituitary-adrenal (HPA) axis with the potential for glucocorticoid insufficiency after withdrawal of treatment. Cushing's syndrome may develop in some patients. Patients receiving high doses of potent topical corticosteroids over extensive areas of skin should have HPA axis function assessed regularly. If signs of HPA axis suppression appear, treatment should be discontinued, the frequency of application reduced, or the product substituted with a less potent corticosteroid.
Recovery of HPA axis function after dose reduction is usually rapid and complete. Rarely, symptoms of corticosteroid withdrawal similar to those seen with systemic therapy may occur.
Use in children: Children may show greater susceptibility than adults to topical-corticosteroid-induced HPA axis suppression and to exogenous corticosteroid effects, owing to higher absorption resulting from a greater body surface area to body weight ratio.
Belogent cream may be used to treat napkin (diaper) dermatitis only when strictly necessary.
If mycotic superinfection of the lesions occurs, additional antifungal therapy is required.
Long-term topical use of gentamicin may lead to bacterial resistance to aminoglycosides. For this reason, topical gentamicin is not recommended in immunosuppressed patients or in other high-risk groups. If resistance or secondary infection develops during treatment, the product must be discontinued and appropriate therapy initiated.
Visual disturbance
Visual disturbance has been reported with both systemic and topical use of corticosteroids. If a patient presents with symptoms such as blurred vision or other visual disturbances, referral to an ophthalmologist should be considered for evaluation of possible causes, which may include cataract, glaucoma or rare conditions such as central serous chorioretinopathy (CSCR), reported following both systemic and topical corticosteroid administration.
This product contains cetostearyl alcohol, which may cause local skin reactions (e.g. contact dermatitis), and chlorocresol, which may cause allergic reactions.
