Diuramid

Pharmacotherapeutic group: Carbonic anhydrase inhibitors. ATC Code: S01EC01 Mechanism of action Acetazolamide is an inhibitor of carbonic anhydrase.‍‍‍‍‍‍​​​‍​​​​​​ By inhibiting the reaction catalysed by this enzyme in the renal tubules, acetazolamide increases the excretion of bicarbonate and of cations, chiefly sodium and potassium, and so promotes alkaline diuresis. Continuous administration of acetazolamide is associated with metabolic acidosis and resultant loss of diuretic activity. Therefore, the effectiveness of Acetazolamide Tablets in diuresis diminishes with continuous use. By inhibiting carbonic anhydrase in the eye, acetazolamide decreases intra-ocular pressure and is therefore useful in the treatment of glaucoma.