Pimethixene

R06AX23(WHO) 1-Methyl-4-(9H-thioxanthen-9-ylidene)piperidine 314-03-4N 4822 4656Y T46J20J26F D07406Y ChEMBL152408Y DTXSID0048476 Interactive image S2c1ccccc1/C(c3c2cccc3)=C4/CCN(C)CC4 InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3YKey:NZLVRVYNQYGMAB-UHFFFAOYSA-NY Pimethixeneis anantihistamineandanticholinergicof thethioxanthenechemical classoriginally developed to treathyperactivity,anxiety,sleep disorders, andallergy. It is also used foranesthesiaand as abronchodilator(to dilate thebronchiandbronchiolesfor more airflow). In combination withpholcodine, it was sold in France by Laboratoires Salvoxyl in the 1970s as theantitussiveSalvodex.Pimethixene alone is still available in Brazil under the trade nameMuricalm. In addition to its other activities, it is a highlypotentbutnon-selectiveserotonin5-HT2Breceptorantagonist.Theselectiveserotonin 5-HT2Breceptor antagonistBF-1wasderivedfrom pimethixene.