Pentetrazol

R07AB03(WHO) 6,7,8,9-Tetrahydro-5H-tetrazolo(1,5-a)azepine 54-95-5Y 5917 5704N WM5Z385K7T D07409N CHEBI:34910N ChEMBL116943N DTXSID7041091 Interactive image C1CCc2nnnn2CC1 InChI=1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2NKey:CWRVKFFCRWGWCS-UHFFFAOYSA-NN Pentylenetetrazol(PTZ), also known aspentylenetetrazole,pentetrazol(INN), andpentamethylenetetrazol, is adrugformerly used as a circulatory and respiratory stimulant. High doses causeconvulsions, as discovered by Hungarian-American neurologist and psychiatristLadislas J. Medunain 1934. It has been used in convulsive therapy, and was found to be effective in treating depression, but side effects, such as uncontrolledseizures, were difficult to avoid.In 1939, pentylenetetrazol was replaced byelectroconvulsive therapy, which is easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US, pentylenetetrazol's approval by theFood and Drug Administration(FDA) was revoked in 1982.It is used in Italy as a cardio-respiratory stimulant in combination withdihydrocodeinein acough suppressantdrug.