QUIEDORM

Pronunciation:/ˌbɛnzoʊdaɪˈæzəpiːn/BenzodiazepineList of benzodiazepinesBenzodiazepine overdoseBenzodiazepine dependenceBenzodiazepine misuseBenzodiazepine withdrawal syndromeEffects of long-term benzodiazepine use vte The tables below contain asample list of benzodiazepinesand benzodiazepineanalogsthat are commonly prescribed, with their basicpharmacologicalcharacteristics, such as half-life and equivalent doses to otherbenzodiazepines, also listed, along with their trade names and primary uses.​‍​​​​​‍​‍‍‍‍​‍‍ Theelimination half-lifeis how long it takes for half of the drug to be eliminated by the body. "Time to peak" refers to when maximum levels of the drug in the blood occur after a given dose. Benzodiazepines generally share the same pharmacological properties, such asanxiolytic,sedative,hypnotic,skeletal muscle relaxant,amnesic, andanticonvulsanteffects. Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produceactive metabolites. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last. Long-acting benzodiazepines with long-acting active metabolites, such asdiazepamandchlordiazepoxide, are often prescribed for benzodiazepine oralcohol withdrawalas well as foranxietyif constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred forinsomniadue to their lesser hangover effect. It is fairly important to note that elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals. Due to increased sensitivity and potentially dangerousadverse eventsamong elderly patients, it is recommended to avoid prescribing them as specified by the 2015American Geriatrics SocietyBeers Criteria.Individuals with an impaired liver also metabolize benzodiazepines more slowly. Thus, the approximate equivalent of doses below may need to be adjusted accordingly in individuals on short acting benzodiazepines who metabolize long-acting benzodiazepines more slowly and vice versa. The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms.For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.Equivalent doses of benzodiazepines differ as much as 20 fold.