Zinc acexamate

ZincL-carnosine(abbreviated asZnC) (beta-alanyl-L-histidinato zinc) (N-(3-aminopropionyl)-L-histidinato zinc), often simply calledzinc carnosine, and also known aspolaprezinc,is amucosalprotectivechelate compound ofzincandL-carnosineinvented by Hamari Chemicals, Ltd.It is a quadridentate 1:1 complex of a polymeric na​‍​​​​​‍​‍‍‍‍​‍‍ture.Although it contains 23% zinc and 77%L-carnosine by mass,zinc carnosine is a molecule and not amixtureof zinc andL-carnosine. It is anapproved drugrequiring amedical prescriptioninJapanandSouth Koreawhere it is clinically used to treatgastric ulcers.Clinical studies have also shown its efficacy for oral mucositis, esophagitis, proctitis, taste alteration and dermatitis during and afterradiotherapy.In theUnited States, zinc carnosine is regulated as aNew Dietary Ingredient, where notification with theUS-FDAis required.InAustralia, it is regulated as acomplementary medicine.InCanada, it is regulated as aNatural Health Product.