Alizapride hydrochloride

USDailyMed:Buspirone AU:B1 N05BE01(WHO) AU:S4(Prescription only)BR:Class C1(Other controlled substances)CA:℞-onlyUK:POM(Prescription only)US:℞-only 8-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione 36505-84-7Yas HCl:33386-08-2 2477 36 DB00490Y 2383Y TK65WKS8HL D07593Y CHEBI:3223Y ChEMBL49Y DTXSID2022707 Interactive image O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1 InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2YKey:QWCRAEMEVRGPNT-UHFFFAOYSA-NY Buspirone, sold under the nameBusparamong others, is ananxiolyticmedication primarily used for the treatment ofgeneralized anxiety disorder.‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ Unlikebenzodiazepines, buspirone does not produce significantsedation,dependence, orwithdrawal symptoms. Buspirone’s principalmechanism of actioninvolvespartial agonismatpostsynapticserotonin5-HT1Areceptorsandfull agonismatpresynaptic5-HT1Aautoreceptors, which initially reduces serotonergic neuron firing. Over time, autoreceptordesensitizationoccurs, leading to increased serotonin release and enhanced serotonergic tone, which may contribute to its clinical efficacy. It has a delayed onset of action of 2–4 weeks. Buspirone also has weakantagonisticeffects atdopamineD2,D3, andD4receptorsandα1- andα2-adrenergic receptors. Buspirone is approved for the management of generalized anxiety disorder. It is sometimes used off-label for otheranxiety disorders, asantidepressantaugmentation in depression, forhypoactive sexual desire disorderin women, antidepressant-induced sexual dysfunction, andbruxism. Buspirone is not effective as asedative–hypnoticormuscle relaxantand does not haveanticonvulsantproperties. Common side effects of buspirone includenausea,headaches,dizziness, and difficulty concentrating.Serious side effects may includemovement disorders,serotonin syndrome, andseizures.Its use inpregnancyappears to be safe but has not been well studied, and use duringbreastfeedinghas not been well studied either. Buspirone was developed in 1968 and approved for medical use in the United States in 1986.It is available as ageneric medication.In 2023, it was the 40th most commonly prescribed medication in the United States, with more than 15million prescriptions.