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1CFH,1CFI,1EDM,1IXA,1MGX,1NL0,1RFN,2WPH,2WPI,2WPJ,2WPK,2WPL,2WPM,3KCG,3LC3,3LC5,4YZU,4Z0K,4ZAE,4WM0,4WMA,4WMI,4WMK,4WN2,4WNH,5EGM,5JBC,5JB9,5JBB,5JB8,5JBA right lobe of liversecondary oocytegonadpancreatic ductal cellskin of thighkidneybloodhuman musculoskeletal systemmuscular systemmuscle left lobe of liverlumbar spinal gangliongallbladdersexually immature organismthoracic diaphragmmedial head of gastrocnemius muscledentate gyrusnucleus of stria terminalispiriform cortexjejunum endopeptidase activitymetal ion bindingpepti‍​‍‍‍​‍‍‍‍‍‍‍‍​‍dase activityserine-type peptidase activityhydrolase activitycalcium ion bindingserine-type endopeptidase activityprotein binding endoplasmic reticulum lumenplasma membraneGolgi lumenextracellular exosomeextracellular regionextracellular spacecollagen-containing extracellular matrix hemostasisblood coagulation, intrinsic pathwayzymogen activationendoplasmic reticulum to Golgi vesicle-mediated transportsignal peptide processingblood coagulation, extrinsic pathwaypeptidyl-glutamic acid carboxylationproteolysisblood coagulation 2158 14071 ENSG00000101981 ENSMUSG00000031138 P00740 P16294 NM_000133NM_001313913 NM_007979NM_001305797 NP_000124NP_001300842 NP_001292726NP_032005 Factor IX(EC3.4.21.22) is one of theserine proteasesinvolved incoagulation; it belongs to peptidase family S1. Deficiency of this protein causeshaemophilia B. It was discovered in 1952 after a young boy namedStephen Christmaswas found to be lacking this exact factor, leading tohaemophilia.Coagulation factor IX is on theWorld Health Organization's List of Essential Medicines.