Question 1

What is Etynodiol used for?

Accepted Answer

Etynodiol diacetate (the diacylated derivative of etynodiol or ethynodiol) is prescribed for the prevention of pregnancy in women who chose to take oral contraceptives.﻿‍‍‍‍‍‍​​​‍​​​​​​﻿ It is a hormonal contraceptive containing two hormones progestin and estrogen. Etynodiol diacetate is used in combination with an estrogen in combined oral contraceptives for women. Oral contraceptive products should not be used unless medically indicated.
Etynodiol diacetate’s primary mechanism is to prevent ov

Question 2

What are the side effects of Etynodiol?

Accepted Answer

• Menstrual disturbances, including prolonged bleeding or spotting and amenorrhea.
• Periodic abdominal bloating and breast tenderness may be due to water retention that can be rel﻿‍‍‍‍‍‍​​​‍​​​​​​﻿ieved with diuretics.
• A decrease in HDL cholesterol.
• Hypogonadism due to its antigonadotropic effects at high dosages (5 to 60 mg/day) used in the treatment of gynecological disorders.
• Androgenic side effects like acne,
hirsutism
and voice changes at high doses (10 to 40 mg/day) only when used a

Question 3

Does Etynodiol interact with other medications?

Accepted Answer

• Finasteride and dutasteride can inhibit the metabolism of norethisterone, the active drug.
• Cytochrome P450 enzyme 3A4 or CYP3A4 is the major metabolizer of norethisterone.﻿‍‍‍‍‍‍​​​‍​​​​​​﻿ Hence inducers of CYP3A4 like rifampicin, bosentan,
carbamazepine
and St. John's wort can increase norethisterone’s metabolism and decrease its plasma levels.
• Rifampin used at the same time as the combination drug can cause increased bleeding and menstrual irregularities. Similar effects are seen but wi

Question 4

What precautions should be taken with Etynodiol?

Accepted Answer

• Smoking is strictly prohibited while taking oral contraceptives.
• Oral contraceptives can affect liver function and lipid levels and can cause fluid retent﻿‍‍‍‍‍‍​​​‍​​​​​​﻿ion.
• Caution should be taken if the women have a history of depression.
• Caution should be taken in breastfeeding women as it may decrease the milk production and can cause jaundice and breast enlargement in the child.
• Oral contraceptives do not afford any protection against venereal diseases and HIV infection.

Question 5

What ATC class does Etynodiol belong to?

Accepted Answer

Etynodiol: ATC G03DC06. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Etynodiol

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