Albumin human, recombinant

1AO6,1BJ5,1BKE,1BM0,1E78,1E7A,1E7B,1E7C,1E7E,1E7F,1E7G,1E7H,1E7I,1GNI,1GNJ,1H9Z,1HA2,1HK1,1HK2,1HK3,1HK4,1HK5,1N5U,1O9X,1TF0,1UOR,1YSX,2BX8,2BXA,2BXB,2BXC,2BXD,2BXF,2BXG,2BXH,2BXI,2BXK,2BXL,2BXM,2BXN,2BXO,2BXP,2BXQ,2I2Z,2I30,2VDB,2VUE,2VUF,2XSI,2XVQ,2XVU,2XVV,2XVW,2XW0,2XW1,2YDF,3A73,3B9L,3B9M,3CX9,3JQZ,3JRY,3LU6,3LU7,3LU8,3SQJ,3TDL,3UIV,4E99,4EMX,4G03,4G04,4HGK,4HGM,4IW1,4IW2,4K2C,4L8U,4L9K,4L9Q,4LA0,4LB9,4LB2,2N0X,2ESG,4S1Y,4N0F,4Z69,4N0U,4K71,2BXE,4BKE,5IJF,5ID7,5IFO,5FUO liverright lobe of liverbody of pancreaskidney tubuleislet of Langerhanshuman kidneyepithelium of colonglomerulusmetanephric glomerulustesticle gallbladderleft lobe of liverfetal liver hematopoietic progenitor cellhuman fetusatrioventricular valveabdominal wallsexually immature organismupper lipwhite adipose tissuemuscle of thorax DNA bindingoxygen bindingchaperone bindingmetal ion bindingantioxidant activityprotein bindingidentical protein bindingpyridoxal phosphate bindingcopper ion bindinglipid bindingtoxic substance bindingfatty acid bindingexogenous protein binding cytoplasmGolgi apparatusblood microparticlemyelin sheathextracellular regionendoplasmic reticulumextracellular exosomeplatelet alpha granule lumennucleusextracellular spaceendoplasmic reticulum lumenprotein-containing c‍​‍‍‍​‍‍‍‍‍‍‍‍​‍omplex sodium-independent organic anion transporthemolysis by symbiont of host erythrocytescellular response to starvationplatelet degranulationnegative regulation of apoptotic processreceptor-mediated endocytosismaintenance of mitochondrion locationretina homeostasisbile acid and bile salt transportnegative regulation of programmed cell deathcellular oxidant detoxificationhigh-density lipoprotein particle remodelingpost-translational protein modificationtransportnegative regulation of protein oligomerization 213 11657 ENSG00000163631 ENSMUSG00000029368 P02768 P07724 NM_000477 NM_009654 NP_000468 NP_033784 Human serum albuminis theserum albuminfound in humanblood. It is the most abundantproteinin humanblood plasma; it constitutes about half ofserumprotein. It is produced in theliver. It is soluble in water, and it ismonomeric. Albumintransports hormones, fatty acids, and other compounds, bufferspH, and maintainsoncotic pressure, among other functions. Albumin is synthesized in the liver as preproalbumin, which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in theGolgi apparatusto produce the secreted albumin. Thereference rangefor albumin concentrations in serum is approximately 35–50 g/L (3.5–5.0 g/dL).It has a serum half-life of approximately 21 days.It has amolecular massof 66.5 kDa. The gene for albumin is located on chromosome 4 in locus 4q13.3 and mutations in this gene can result in anomalous proteins. The human albumin gene is 16,961nucleotideslong from the putative 'cap' site to the first poly(A) addition site. It is split into 15 exons that are symmetrically placed within the 3 domains thought to have arisen by triplication of a single primordial domain. Human serum albumin (HSA) is a highly water-soluble globular monomeric plasma protein with a relative molecular weight of 67 KDa, consisting of 585 amino acid residues, one sulfhydryl group and 17 disulfide bridges. Among nanoparticulate carriers, HSA nanoparticles have long been the center of attention in the pharmaceutical industry due to their ability to bind to various drug molecules, great stability during storage andin vivousage, no toxicity and antigenicity,biodegradability, reproducibility, scale up of the production process and a better control over release properties. In addition, significant amounts of drug can be incorporated into the particle matrix because of the large number of drug binding sites on the albumin molecule.