Collagenase clostridium histolyticum

EUEMA:by Collagenase clostridium histolyticumUSDailyMed:Collagenase_clostridium_histolyticum M09AB02(WHO) US:℞-onlyIn general: ℞ (Prescription only) 9001-12-1Y 138909 DB00048N none 9X7O8V25IT C00816 DTXSID401010862 Collagenaseclostridium histolyticumis anenzymeproduced by the bacteriumClostridium histolyticumthat dismantlescollagen.‍‍‍‍‍‍​​​‍​​​​​​ It is used as a powder-and-solvent injection kit for the treatment ofDupuytren's contracture, a condition where the fingers bend towards the palm and cannot be fully straightened, andPeyronie's disease, a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. BioSpecifics Technologies developed the preparation, which is manufactured and marketed byEndo PharmaceuticalsasXiaflexin the US and bySobiasXiapexin Europe. Biochemically, it is a mixture of twoC. histolyticumcollagenases,ColHandColG. A similar ointment preparation calledSantylcontains one or many collagenases from the same bacterium, but it is unclear which.