AKANTIOR

28757-47-3Y32289-58-0(HCl)Y CHEBI:149520 none D08399D13228 322U039GMFY4XI6112496(HCl)Y DTXSID7041099 EU:Rx-only Polyhexanide(polyhexamethylene biguanide,PHMB) is apolymerused as adisinfectantandantiseptic. Indermatologicaluse,it is spelledpolihexanide(INN) and sold under various brand names.PHMB has been shown to be effective againstPseudomonas aeruginosa,Staphylococcus aureus,Escherichia coli,Candida albicans,Aspergillus brasiliensis,enterococci, andKlebsiella pneumoniae.Polihexanide, sold under the brand nameAkantioris amedicationused for the treatment ofAcanthamoebakeratitis. Products containing PHMB are used for inter-operative irrigation, pre- and post-surgery skin andmucous membranedisinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic footulcerand burn wound management, routine antisepsis during minor incisions,catheterization, first aid, surface disinfection, and linen disinfection.PHMB eye drops have been used as a treatment for eyes affected byAcanthamoebakeratitis. It is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil. PHMB is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The PHMB hydrochloride salt (solution) is used in the majority of formulations.