Almotriptan - Indications, Dosage, Side Effects and Precautions

V03AZ01(WHO) 64-17-5 702 2299 DB00898Y 682Y 3K9958V90M D00068 CHEBI:16236Y ChEMBL545Y EOH (PDBe,RCSB PDB) Interactive image CCO InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3Key:LFQSCWFLJHTTHZ-UHFFFAOYSA-N Thepharmacology of ethanolinvolves both pharmacodynamics (how it affects the body) and pharmacokinetics (how the body processes it).‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ In the body,ethanolprimarily affects the central nervous system, acting as a depressant and causing sedation, relaxation, and decreased anxiety. The complete list of mechanisms remains an area of research, but ethanol has been shown to affect ligand-gated ion channels, particularly theGABAAreceptor. After oral ingestion, ethanol is absorbed via the stomach and intestines into the bloodstream. Ethanol is highly water-soluble and diffuses passively throughout the entire body, including the brain. Soon after ingestion, it begins to be metabolized, 90% or more by the liver.Onestandard drinkis sufficient to almost completely saturate the liver's capacity to metabolize alcohol.The main metabolite is acetaldehyde, a toxic carcinogen. Acetaldehyde is then further metabolized into ionic acetate by the enzyme aldehyde dehydrogenase (ALDH).Acetateis not carcinogenic and has low toxicity,but has been implicated in causinghangovers.Acetate is further broken down into carbon dioxide and water and eventually eliminated from the body through urine and breath. 5 to 10% of ethanol is excreted unchanged in the breath, urine, and sweat.