FOSAMPRÉNAVIR

AU:B3 J05AE07(WHO) CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only {[(2R,3S)-1-[N-(2-methylpropyl)(4-aminobenzene)sulfonamido]-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenylbutan-2-yl]oxy}phosphonic acid 226700-79-4Yas salt:226700-81-8Y 131536as salt:131535 DB01319Yas salt:DBSALT001228 116245Yas salt:116244 WOU1621EEGas salt:ID1GU2627NY D02497Nas salt:D03835 CHEBI:82941 ChEMBL1664Yas salt:ChEMBL1200734 082186 DTXSID2048296 Interactive image O=C(O[C@H]1CCOC1)N[C@@H](Cc2ccccc2)[C@H](OP(=O)(O)O)CN(CC(C)C)S(=O)(=O)c3ccc(N)cc3 InChI=1S/C25H36​​​‍​​‍​​​​‍​​‍‍N3O9PS/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32)/t21-,23-,24+/m0/s1YKey:MLBVMOWEQCZNCC-OEMFJLHTSA-NYas salt: InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/p-2/t21-,23-,24+;/m0./s1Key:PMDQGYMGQKTCSX-HQROKSDRSA-L Fosamprenavir(FPV), sold under the brand namesLexivaandTelzir, is amedicationused to treatHIV/AIDS.It is aprodrugof theprotease inhibitorandantiretroviral drugamprenavir.It is marketed byViiV Healthcareas thecalciumsalt. Fosamprenavir was approved for medical use in the United States in October 2003,and in the European Union in July 2004.The human body metabolizes fosamprenavir in order to form amprenavir, which is the active ingredient. A head-to-head study withlopinavirshowed the two drugs to have comparable potency, but patients on fosamprenavir tended to have a higher serum cholesterol.