Idasanutlin

548472-68-0Y Interactive image CHEBI:46742 ChEMBL191334N 187530 DB17039 637-233-8 16755649 53IA0V845CY InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1Key: BDUHCSBCVGXTJM-IZLXSDGUSA-N CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl Nutlinsare a family of small molecule,cis-imidazolineanalogs, which inhibit the interaction betweenMDM2and tumor suppressorp53, stabilizing p53 and triggering cell death and senescence. Three nutlins were discovered in the initial small molecule screen (nutlin-1, nutlin-2, and nutlin-3),but nutlin-3 is most commonly used in anti-cancer studies.Nutlins disrupt the p53–MDM2 interaction by occupying a p53-binding pocket of MDM2.Many tumors that express normal p53 and normal or elevated levels of MDM2 may be targeted using nutlin.Nutlin-3 acts quickly in vitro, leading to increased levels of p53 protein within minutes. The more potent of the twoenantiomers, nutlin-3a ((–)-nutlin-3), can be synthesized in a highly enantioselective fashion.Several derivatives of nutlin, such as RG7112 and RG7388 (Idasanutlin) have been developed and progressed into human studies, but have not yet shown improved survival and may cause toxicity.Imidazoline core based on the methoxyphenyl substituents also stabilizes p53.Since its discovery in 2003, the nutlin core has been modified to obtain molecules with additional properties, such as increased solubility, irreversible MDM2 inhibitors, improved binding to MDMX, the PROTAC methodology, dual-action molecules, and fluorescent probes.