Docetaxel

USDailyMed:Abiraterone_acetate AU:D L02BX03(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) [(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 154229-18-2Y154229-19-3 (abiraterone) 9821849 9288 DBSALT001173Y 7997598Y EM5OCB9YJ6 D09701 CHEBI:68639 ChEMBL271227Y DTXSID3049043 Interactive image CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC=C4C5=CN=CC=C5)C)C InChI=1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1YKey:UVIQSJCZCSLXRZ-UBUQANBQSA-NY Abiraterone acetate, sold under the brand nameZytigaamong others, is a medication used to treatprostate cancer.Specifically it is used together with acorticosteroidformetastaticcastration-resistant prostate cancer(mCRPC) and metastatic high-risk castration-sensitive prostate cancer (mCSPC).It should either be used followingremoval of the testiclesor along with agonadotropin-releasing hormone (GnRH) analog.It is taken by mouth. Common side effects includetiredness,vomiting,headache,joint pain,high blood pressure,swelling,low blood potassium,high blood sugar,hot flashes,diarrhea, andcough.Other severe side effects may includeliver failureandadrenocortical insufficiency.In males whose partners can becomepregnant,birth controlis recommended.Supplied as abiraterone acetate it is converted in the body to abiraterone.Abiraterone acetate works bysuppressing the production of androgens– specifically itinhibits CYP17A1– and thereby decreases theproductionoftestosterone.In doing so, it prevents the effects of thesehormonesin prostate cancer. Abiraterone acetate was described in 1995, and approved for medical use in the United States and the European Union in 2011.It is on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.