Thioplan Injection

( ARTG ) Thiotepa has been tried with varying results in the palliation of a wide variety of neoplastic diseases. However, the most consistent results have been seen in the following tumours: . adenocarcinoma of the breast or ovary; . for controlling intracavitary effusions secondary to diffuse or localised neoplastic diseases of various serosal cavities and . for the treatment of superficial papillary carcinoma of the urinary bladder. While now largely superseded by other treatments, thiotepa has been effective against other lymphomas, such as lymphosarcoma and Hodgkin's disease. Complete response rates of 27% and 48% were obtained with a dose of30mg thiotepa in the treatment of bladder cancer.