Pharmacotherapeutic group: ophthalmologicals, other antiallergics, ATC code: S01GX01.
Sodium cromoglicate stabilizes mast cell membranes, thereby preventing their degranulation and the release of mediators of allergic reaction and inflammation upon contact with an antigen. Through this mechanism, cromoglicate prevents both the release of preformed mediators (e.g., histamine, kinins), which mediate immediate type I allergic reactions, and mediators synthesized only after provocation (prostaglandins, leukotrienes), which mediate delayed type IV reactions.
Cromoglicate also prevents the activation of calcium channels. It blocks the calcium channel associated with the IgE receptor, thereby preventing calcium influx into the cell after IgE binding. This mechanism also inhibits mast cell degranulation and histamine release.
⚠️ Warnings
During treatment — and during allergic conjunctivitis in general — the patient should not wear contact lenses. If the physician permits their use for exceptional reasons, the patient must remove the lenses before application of the product and must not reinsert them for at least 15 minutes after instillation.
