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( ARTG ) Rheumatoid Arthritis in adults,REMSIMA, in combination with methotrexate, is indicated for the reduction of signs and symptoms and prevention of structural joint damage (erosions and joint space narrowing) in:,- patients with active disease despite treatment with methotrexate,- patients with active disease who have not previously received methotrexate.,REMSIMA should be given in combination with methotrexate.‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ Efficacy and safety in Rheumatoid Arthritis have been demonstrated only in combination with methotrexate.,Ankylosing Spondylitis,REMSIMA is indicated for the reduction of signs and symptoms and improvement in physical function in patients with active disease.,Psoriatic arthritis,REMSIMA is indicated for the treatment of the signs and symptoms, as well as for the improvement in physical function in adult patients with active and progressive psoriatic arthritis who have responded inadequately to disease-modifying anti-rheumatic drug (DMARD) therapy. REMSIMA may be administered in combination with methotrexate.,Psoriasis,REMSIMA is indicated for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or conventional systemic treatments have been inadequate or are inappropriate. Safety and efficacy beyond 12 months have not been established.,Crohns Disease in Adults and in Children and adolescents (6 to 17 years),REMSIMA is indicated for the treatment of moderate to severe Crohns disease, to reduce the signs and symptoms and to induce and maintain clinical remission in patients who have an inadequate response to conventional therapies.,Refractory Fistulising Crohns Disease,REMSIMA is indicated for reducing the number of draining enterocutaneous and rectovaginal fistulas and maintaining fistula closure in adult patients.,Ulcerative colitis in Adults and in Children and adolescents (6 to 17 years),REMSIMA is indicated for the treatment of moderately severe to severe active ulcerative colitis in patients who have had an inadequate response to conventional therapy.