What is Dovato used for?

( ARTG ) DOVATO (a fixed dose combination of dolutegravir and lamivudine) is indicated for the treatment of Human Immunodeficiency Virus-1 (HIV-1) infection in adults and adolescents (from 12 years of age weighing at least 40kg): in antiretroviral treatment-naïve patients with no antiretroviral treatment history who have no known or suspected resistance to either antiretroviral component; or to replace the current antiretroviral regimen in those who are virologically suppre

What are the side effects of Dovato?

You can help ensure medicines are safe by reporting the side effects you experience. You can report side effects to your doctor, or directly at www.tga.gov.au/reporting-problems

Can Dovato be used during pregnancy?

( AHT ) For the active ingredient dolutegravir + lamivudine You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

What ATC class does Dovato belong to?

Dovato: ATC J05AR. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Dovato

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

USDailyMed:Dolutegravir AU:B1 J05AJ03(WHO)J05AR13(WHO)J05AR21(WHO) AU:S4(Prescription only)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide 1051375-16-6N 54726191 7365 DB08930 25051637Y DKO1W9H7M1 D10066 CHEBI:76010 ChEMBL1229211Y DLU (PDBe,RCSB PDB) DTXSID90909356 Interactive image C[C@@H]1CCO[C@@H]2N1C(=O)c3c(c(=O)c(cn3C2)C(=O)NCc4ccc(cc4F)F)O InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1‍‍‍‍‍H3,(H,23,28)/t10-,15+/m1/s1YKey:RHWKPHLQXYSBKR-BMIGLBTASA-NY Dolutegravir(DTG), sold under the brand nameTivicay, is anantiretroviral medicationused, together with other medication, to treatHIV/AIDS.It may also be used, as part ofpost exposure prophylaxis, to prevent HIV infection following potential exposure.It is taken by mouth. Common side effects include trouble sleeping, feeling tired,diarrhea,high blood sugar, and headache.Severe side effects may includeallergic reactionsandliver problems.Concerns that usage duringpregnancycan result in harm to the baby have been refuted by further studies that show there is no statistical difference inneural tube defectsfrom the usage of dolutegravir compared to other antiretrovirals.It is unclear if use duringbreastfeedingis safe.Dolutegravir is anHIV integrase strand transfer inhibitorwhich blocks the functioning ofHIV integrasewhich is needed forviral replication. Dolutegravir was approved for medical use in the United States in 2013.It is on theWorld Health Organization's List of Essential Medicines.Single tablet regimen combination drugs containing dolutegravir, such asdolutegravir/rilpivirine,dolutegravir/lamivudine, andabacavir/dolutegravir/lamivudine, are also available.As of 2019, theWorld Health Organization(WHO) recommends DTG as the first- and second-line treatment for all persons with HIV.

Dovato

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