What is Etelcalcetide used for?

• Etelcalcetide has been approved by US FDA on Feb.2017 for the treatment of secondary hyperparathyroidism (HPT) in adults who suffer chronic kidney disease and undergo hemodialysis . • Secondary hyperparathyroidism is a condition in which the body produces the excess parathyroid hormone in response to a low level of calcium in the blood which is usually observed in chronic kidney disease patients. • Etelcalcetide acts by activating the calcium-sensing receptor in the parathyroid gland and si

What are the side effects of Etelcalcetide?

Common: Diarrhea, nausea, vomiting, low blood calcium level, muscle spasm Skin: Rashes , hives, itching, swelling of the face Central nervous system: Headache, paresthesia Cardiovascular: Heart failure, ECG abnormalities, low blood pressure Endocrine: Decreased levels of phosphate and calcium levels in blood, increase in blood potassium levels Others: Blood vomiting, black or bright red stools, muscle pain, allergic reaction

Does Etelcalcetide interact with other medications?

• Combination of etelcalcetide with cinacalcet should be avoided because of the additional calcium lowering effect.

What precautions should be taken with Etelcalcetide?

• Patients should be monitored for low blood calcium levels or symptoms caused by it such as seizures, muscle spasm, myalgia, and paresthesias. The blood parathyroid hormone level should also be monitored regularly. • Etelcalcetide therapy may worsen the existing heart failure or cause ventricular arrhythmia especially in patients with ECG abnormalities like congenital long QT syndrome. A strict monitoring is required in such cases. • Patients with gastritis, stomach ulcers or other upper gas

What ATC class does Etelcalcetide belong to?

Etelcalcetide: ATC H05BX04. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Etelcalcetide

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

Etelcalcetide — Description, Dosage, Side Effects | PillsCard

USDailyMed:Etelcalcetide H05BX04(WHO) US:℞-onlyEU:Rx-only (6R,9R,12R,15R,18R,21R,24S,29R)-24-Acetamido-1,29-diamino-12,15,18-tris(3-carbamimidamidopropyl)-6-carbamoyl-1-imino-9,21-dimethyl-8,11,14,17,20,23-hexaoxo-26,27-dithia-2,7,10,13,16,19,22-heptaazatria contan-30-oic acid 1262780-97-1as salt:1334237-71-6 71511839 DB12865as salt:DBSALT002195 32697932as salt:32698192 60ME133FJBas salt:72PT5993DU D10676as salt:D10677 as salt:ChEMBL3545183 DTXSID70155132 Interactive image C[C@H](C(=O)N[C@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@@H](C(=O)O)N)NC(=O)C InChI=1S/C38H73N21O10S2/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52)/t18-,19-,21+,22-,23-,24-,25-,26-/m1/s1Key:ANIAZGVDEUQPRI-ZJQCGQFWSA-Nas salt: InChI=1S/C38H73N21O10S2.ClH/c1-18(28(62)56-22(27(40)61)8-4-12-49-35(41)42)53-30(64)23(9-5-13-50-36(43)44)58-32(66)25(11-7-15-52-38(47)48)59-31(65)24(10-6-14-51-37(45)46)57-29(63)19(2)54-33(67)26(55-20(3)60)17-71-70-16-21(39)34(68)69;/h18-19,21-26H,4-17,39H2,1-3H3,(H2,40,61)(H,53,64)(H,54,67)(H,55,60)(H,56,62)(H,57,63)(H,58,66)(H,59,65)(H,68,69)(H4,41,42,49)(H4,43,44,50)(H4,45,46,51)(H4,47,48,52);1H/t18-,19-,21+,22-,23-,24-,25-,26-;/m1./s1Key:KHQMSZGKHGQUHG-WZDHWKSBSA-N Etelcalcetide, sold under the brand nameParsabiv, is acalcimimeticmedication for the treatment ofsecondary hyperparathyroidismin people undergoinghemodialysis. It is administered intravenously at the end of each dialysis session.Etelcalcetide functions by binding to and activating thecalcium-sensing receptorin theparathyroid gland.Parsabiv is currently owned byAmgenand Ono Pharmaceuticals in Japan.

Etelcalcetide

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