What is Ketoconazole used for?

This medication is an anti-fungal agent, prescribed for jock itch, athlete's foot and other infections. It interferes with the formation of the fungal cell membrane and kills fungi.

What are the side effects of Ketoconazole?

♦ Headache, dizziness, drowsiness, fever, chills, sensitivity to light, diarrhea, nausea, vomiting, breast enlargement in male, impotence, decrease in platelet counts and white blood cells, anemia, projection of skull bone, hair loss.

Does Ketoconazole interact with other medications?

Theconcomitantuse of the following medications are contraindicated with ketoconazole tablets: methadone,disopyramide,dronedaroneirinotecan,lurasidone,colchicinealprazolam, oralmidazolam, oraltriazolamfelodipine,ranolazine,tolvaptan,eplerenoneHMG-CoA reductase inhibitors:lovastatin,simvastatinergot alkaloids:ergotamine,dihydroergotamine,ergometrine,methylergometrineOthers:cisapride,nisoldipine,dofetilide,pimozide The following medications are not recommended with ketoconazole: c

Can Ketoconazole be used during pregnancy?

Ketoconazole is categorized aspregnancy category C(Risk not ruled out) in the US.Research in animals has shown it to causeteratogenesiswhen administered in high doses.A subsequent trial in Europe failed to show a risk toinfantsof mothers receiving ketoconazole.

What precautions should be taken with Ketoconazole?

• Caution should be exercised in patients with history of liver disease, alcoholism, blood problems (eg, prophyria), any allergy, who are taking other medications, during pregnancy and breastfeeding. • It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication. • It may affect blood sugar level; monitor sugar level regularly.

Who manufactures Ketoconazole?

Agenzia Industrie Difesa-Stabilimento Chimico Farmaceutico Militare

What ATC class does Ketoconazole belong to?

Ketoconazole: ATC D01AC08. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Ketoconazole

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

USDailyMed:Ketoconazole AU:B3 J02AB02(WHO)D01AC08(WHO),G01AF11(WHO),H02CA03(WHO) UK:POM(Prescription only)US:℞-onlyEU:Rx-onlyIn general: ℞ (Prescription only) 1-[4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone 65277-42-1Y 382347576 2568 DB01026Y 401695Y3691 R9400W927I D00351Y CHEBI:48336Y ChEMBL75YChEMBL157101 KTN (PDBe,RCSB PDB) DTXSID20273956 Interactive image O=C(N5CCN(c4ccc(OC[C@@H]1O[C@](OC1)(c2ccc(Cl)cc2Cl)Cn3ccnc3)cc4)CC5)C InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1YKey:XMAYWYJOQHXEEK-OZXSUGGESA-NY Ketoconazole, sold under the brand‍‍‍‍‍‍‍ nameNizoral, among others, is anantiandrogen,antifungal, andantiglucocorticoidmedication used to treat a number offungal infections.Applied to the skin it is used forfungal skin infectionssuch astinea,cutaneous candidiasis,pityriasis versicolor,dandruff, andseborrheic dermatitis.Takenby mouthit is a less preferred option and recommended for only severe infections when other agents cannot be used.Other uses include treatment ofexcessive male-patterned hair growth in womenandCushing's syndrome. Commonside effectswhenapplied to the skininclude redness.Common side effects when taken by mouth includenausea,headache, andliver problems.Liver problems may result in death or the need for aliver transplantation.Other severe side effects when taken orally includeQT prolongation,adrenocortical insufficiency, andanaphylaxis.It is animidazoleand works by hindering the production ofergosterolrequired for the fungalcell membrane, thereby slowing growth. Ketoconazole was patented in 1977 by Belgian pharmaceutical companyJanssen, and came into medical use in 1981.It is available as ageneric medicationand formulations that are applied to the skin areover the counterin theUnited Kingdom.In 2023, it was the 140th most commonly prescribed medication in the United States, with more than 3million prescriptions.The formulation that is taken by mouth waswithdrawnin the European Union and in Australia in 2013,and in China in 2015.In addition, its use was restricted in the United States and Canada in 2013.

Ketoconazole

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