Alpicort

Pharmacotherapeutic group: Corticosteroids, plain, ATC code: S01BA04 Mechanism of action The actions of corticosteroids are mediated by the binding of the corticosteroid molecules to receptor molecules located within sensitive cells.‍​‍‍‍​‍‍‍‍‍‍‍‍​‍ Corticosteroid receptors are present in human trabecular meshwork cells and in rabbit iris ciliary body tissue. Prednisolone, in common with other corticosteroids, will inhibit phospholipase A2 and thus decrease prostaglandin formation. The activation and migration of leucocytes will be affected by prednisolone. A 1% solution of prednisolone has been demonstrated to cause a 5.1% reduction in polymorphonuclear leucocyte mobilisation to an inflamed cornea. Corticosteroids will also lyse and destroy lymphocytes. These actions of prednisolone all contribute to its anti-inflammatory effect.