Spring 2026 is bringing higher pollen counts across Europe, and millions are reaching for antihistamines. But with so many options available, how do you choose the right one?

Modern antihistamines (second-generation) are the preferred choice because they cause less drowsiness than older medications like diphenhydramine (Benadryl).

Dosage: 10mg once daily for adults

Onset: 1 hour

Duration: 24 hours

Pros: Fast-acting, effective for both indoor and outdoor allergies

Cons: May cause mild drowsiness in some people (~10%)

Status: OTC in most EU countries and the US

Dosage: 10mg once daily for adults

Onset: 1-3 hours

Duration: 24 hours

Pros: Least likely to cause drowsiness, safe for pilots and drivers

Cons: Slightly slower onset than cetirizine

Status: OTC in most countries

Dosage: 120-180mg once daily for adults

Onset: 1-2 hours

Duration: 24 hours

Pros: Zero drowsiness, does not cross blood-brain barrier

Cons: May be less effective for severe symptoms

Status: OTC in most countries, some formulations Rx

For most people with seasonal allergies, any second-generation antihistamine will work well. Choose based on your priorities:

- Need to stay alert? Fexofenadine or loratadine

- Want fastest relief? Cetirizine

- Severe symptoms? Cetirizine or consider adding a nasal corticosteroid

1. Start antihistamines before symptoms begin — they work better as prevention

2. Check pollen forecasts and limit outdoor time on high-count days

3. Shower and change clothes after being outside

4. Keep windows closed during peak pollen hours (5-10 AM)

5. Consider adding nasal saline rinses to your routine

If OTC antihistamines aren't controlling your symptoms, see your doctor. You may benefit from prescription-strength medications, immunotherapy (allergy shots), or a combination approach.

Use PillsCard to compare all available antihistamines in your country, check prices at local pharmacies, and find the best option for you.