LOKELMA

• Patients should be advised to adjust or minimize the intake of sodium or sodium-rich foods to avoid the risk of fluid accumulation or edema. • Patients with a history of mild kidney disease or heart disease should stop taking sodium therapy to reduce the fluid overload. In such cases, the physician can recommend increased diuretic doses to excrete sodium via urine. • Fiber-rich foods should be taken during treatment with sodium zirconium cyclosilicate if the condition of constipation worsens. • Patients must be strictly monitored for their heart and kidney function during treatment with sodium zirconium cyclosilicate and any changes in weight, ECG, and blood pressure should not be ignored. • Treatment with sodium zirconium cyclosilicate can be discontinued if the potassium level in the blood reduces to less than 3.5 mmol/L. • The dose of sodium zirconium cyclosilicate can be adjusted based on the patient’s potassium level in the blood, intake of potassium supplements, and progressive kidney function if any.