FLUOXETINE HYDROCHLORIDE

USDailyMed:Fluoxetine AU:C N06AB03(WHO)QN06AB03(WHO) AU:S4(Prescription only)BR:Class C1(Other controlled substances)CA:℞-onlyUK:POM(Prescription only)US:℞-onlyEU:Rx-only N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine 54910-89-3Yas HCl:56296-78-7Y 3386as HCl:62857 203 DB00472Yas HCl:DBSALT000087Y 3269Yas HCl:56589Y 01K63SUP8Das HCl:I9W7N6B1KJY D00326Yas HCl:D00823Y CHEBI:5118Yas HCl:CHEBI:5119Y ChEMBL41Yas HCl:ChEMBL1201082Y RFX (PDBe,RCSB PDB) DTXSID7023067 Interactive image CNCCC(c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3YKey:RTHCYVBBDHJXIQ-UHFFFAOYSA-NY Fluoxetine, sold under the brand nameProzac, among others, is anantidepressant medicationof theselective seroton‍‍‍‍‍‍​​​‍​​​​​​in reuptake inhibitor(SSRI) classused for the treatment ofmajor depressive disorder,anxiety,obsessive–compulsive disorder(OCD),panic disorder,premenstrual dysphoric disorder, andbulimia nervosa.It is also approved for treatment of major depressive disorder in adolescents and children 8 years of age and over.It has also been used to treatpremature ejaculation.Fluoxetine istaken by mouth. Common side effects of Fluoxetine includeloss of appetite,nausea,diarrhea,headache,trouble sleeping,dry mouth, andsexual dysfunction. In some patients, sexual dysfunction may persist even after the drug is discontinued, a condition known aspost-SSRI sexual dysfunction.Serious side effects includeserotonin syndrome,mania,seizures, an increased risk ofsuicidal behavior, and an increased risk ofbleeding. Fluoxetine was invented byEli Lilly and Companyin 1972. Eli Lilly filed a new drug application for the US Food and Drug Administration in 1974, which was accepted in 1977.It subsequently entered medical use in 1986.It is on theWorld Health Organization's List of Essential Medicinesand is available as ageneric medication.In 2023, it was the eighteenth most commonly prescribed medication in the United States and the fourth most common antidepressant, with more than 27million prescriptions. Eli Lilly also markets fluoxetine in a fixed-dose combination witholanzapineasolanzapine/fluoxetine(Symbyax), which was approved by the USFood and Drug Administration(FDA) for the treatment of depressive episodes ofbipolar I disorderin 2003 and fortreatment-resistant depressionin 2009.