Fluoxetine vs Sertraline

Q: What is the difference between Fluoxetine and Sertraline?

Fluoxetine (INN: FLUOXETINE (FLUOXETINE HYDROCHLORIDE), ATC N06AB03) and Sertraline (INN: SERTRALINE HYDROCHLORIDE, ATC N06AB06) differ in active substance, indications, and safety profile. See the side-by-side table below for dosage, contraindications, and side effects.

Q: Can I take Fluoxetine and Sertraline together?

Combination safety depends on both drugs' mechanisms and your health profile. Check interactions in our database and always consult your doctor or pharmacist before combining.

Q: Which is safer, Fluoxetine or Sertraline?

Safety is patient-specific — both drugs are approved by regulatory authorities when used per label. The better choice depends on your condition, other medications, allergies, and comorbidities. Consult a healthcare professional for personalized advice.

Description, Dosage, Side Effects, Contraindications. Data from EMA, URPL, openFDA and other regulatory sources.

N06AB03

Fluoxetine

FLUOXETINE (FLUOXETINE HYDROCHLORIDE)

e.g. HealthdirectFree Australian health advice you can count on.

N06AB06

Sertraline

SERTRALINE HYDROCHLORIDE

TABLET, FILM COATED

	Fluoxetine	Sertraline
Active Substances	FLUOXETINE (FLUOXETINE HYDROCHLORIDE)	SERTRALINE HYDROCHLORIDE
ATC Code	N06AB03	N06AB06
Form	—	TABLET, FILM COATED
Dosage	—	100 mg/1
Route	—	ORAL
Manufacturer	APOTEX INC	Aphena Pharma Solutions - Tennessee, LLC
Indications	( ARTG ) Treatment of Major depression. Treatment of Obsessive Compulsive Disorder. Treatment of Premenstrual Dysphoric Disorder (PMDD) as defined by DSM-IV criteria.,The essential features of PMDD, according to the Diagnostic and Statistical Manual-4th edition (DSM-IV) include markedly depressed mood, anxiety or tension, affective lability and persistent anger or irritability.‍‍‍‍‍‍‍ Other features include decreased interest in usual activities, difficulty concentrating, lack of energy, change in appetite or sleep and feeling out of control. Physical symptoms associated with PMDD include breast tenderness, headache, joint and muscle pain, bloating and weight gain. These symptoms occur regularly during the luteal phase and remit within a few days following onset of menses; the disturbance markedly interferes with work or school or with usual social activities and relationships with others.

FAQ

What is the difference between Fluoxetine and Sertraline?

Fluoxetine (INN: FLUOXETINE (FLUOXETINE HYDROCHLORIDE), ATC N06AB03) and Sertraline (INN: SERTRALINE HYDROCHLORIDE, ATC N06AB06) differ in active substance, indications, and safety profile. The table above summarizes the clinical differences from regulatory documents.

Can I take Fluoxetine and Sertraline together?

Combination safety depends on mechanisms and your health profile. Use our interactions checker and always consult your doctor or pharmacist before combining medications.

Which is safer, Fluoxetine or Sertraline?

Both drugs are approved when used per label. Safety is patient-specific — the better choice depends on your condition, other medications, allergies, and comorbidities. Consult a healthcare professional for personalized advice.

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.