CARVEDILOL

USDailyMed:Carvedilol C07AG02(WHO) In general: ℞ (Prescription only) (±)-[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine 72956-09-3Y 2585 551 DB01136Y 2487Y 0K47UL67F2 D00255Y CHEBI:3441Y ChEMBL723Y CVD (PDBe,RCSB PDB) DTXSID8022747 Interactive image COc1ccccc1OCCNCC(O)COc3cccc4[nH]c2ccccc2c34 InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3YKey:OGHNVEJMJSYVRP-UHFFFAOYSA-NY Carvedilol, sold under the brand nameCoregamong others, is abeta blockermedication, that may be prescribed for the t‍‍‍‍‍‍​​​‍​​​​​​reatment ofhigh blood pressure(hypertension) and chronicheart failure with reduced ejection fraction(also known as HFrEF or systolic heart failure).Beta-blockers as a collective medication class are not recommended as routine first-line treatment of high blood pressure for all patients, due to evidence demonstrating less effective cardiovascular protection and a less favourable safety profile when compared to other classes of blood pressure-lowering medications. Commonside effectsincludedizziness,tiredness,slowed heart rate,low blood pressure,nausea, andshortness of breath.Severe side effects may includebronchospasm.Safety duringpregnancyorbreastfeedingis unclear.Use is not recommended in those withliver problems.Carvedilol is anonselective beta blockerandalpha-1 blocker.How it improves outcomes is not entirely clear but may involvedilation of blood vessels. Carvedilol was patented in 1978 and approved for medical use in the United States in 1995.Carvedilol is a therapeutic alternative on theWorld Health Organization's List of Essential Medicines.It is available as ageneric medication.In 2023, it was the 35th most commonly prescribed medication in the United States, with more than 16million prescriptions.