Larotrectinib

1.Monitor liver function tests every two weeks during the first month and after that monthly.‍‍‍‍‍‍​​​‍​​​​​​ Reduce the starting dose of larotrectinib in patients with moderate liver function impairment. 2.Neurological adverse effects like gait disturbances, dizziness, tremors, delirium, memory impairment can be seen. 3.Patients are advised not to operate heavy machines if they experience these adverse effects. 4. In females who are able to get pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given. 5. In males with female partners who are able to pregnant, proper contraceptives should be used during the treatment and one week after the last dose is given. 6.Patients should inform their doctors about all the medications they take including herbal medications, OTC products, and vitamin supplements. 7.Do not eat grapefruit or drink grapefruit juice. Do not take St John Wort.