What is Azathioprine VIS used for?

Azathioprine is used as an immunosuppressant antimetabolite either alone or, more commonly, in combination with other agents (usually corticosteroids) and procedures which influence the immune response. Therapeutic effect may be evident only after weeks or months and can include a steroid-sparing effect, thereby reducing the toxicity associated with high dosage and prolonged usage of corticosteroids. Azathioprine, in combination with corticosteroids and/or other immunosuppressi

What pharmaceutical form is Azathioprine VIS available in?

Azathioprine VIS: Tabletki 50 mg (doustna)

Is Azathioprine VIS OTC or prescription only?

Azathioprine VIS requires a doctor's prescription.

What are the side effects of Azathioprine VIS?

Summary of the safety profile For this product there is no modern clinical documentation which can be used as support for determining the frequency of undesirable effects. Undesirable effects may vary in their incidence depending on the indication. The most important adverse reactions include bone marrow depression, most frequently expressed as leukopenia, thrombocytopenia or anaemia; viral, fungal and bacterial infections; life-threatening liver injury; hypersensitivity, Steve

Who should NOT take Azathioprine VIS?

Hypersensitivity to azathioprine or to any of the excipients listed in section 6.1. Hypersensitivity to 6-mercaptopurine should alert the prescriber to probable hypersensitivity to azathioprine.

Does Azathioprine VIS interact with other medications?

Food, milk and dairy products The administration of azathioprine with food may decrease systemic exposure slightly but this is unlikely to be of clinical significance (see section 4.8). Therefore, azathioprine may be taken with food or on an empty stomach, but patients should standardise the method of administration. The dose should not be taken with milk or dairy products since they contain xanthine oxidase, an enzyme which metabolises 6–mercaptopurine and might therefore lead

Can Azathioprine VIS be used during pregnancy?

Fertility The specific effect of azathioprine therapy on human fertility is unknown. Pregnancy Substantial transplacental and transamniotic transmission of azathioprine and its metabolites from the mother to the foetus have been shown to occur. Azathioprine should not be given to patients who are pregnant or likely to become pregnant in the near future without careful assessment of risk versus benefits. Evidence of the teratogenicity of azathioprine in man is equivocal. As with

What precautions should be taken with Azathioprine VIS?

Safe handling Health professionals who handle uncoated azathioprine tablets should follow guidelines for the handling of cytotoxic medicinal products according to prevailing local recommendations and/or regulations. Provided that the film-coating is intact, there is no risk in handling film-coated azathioprine tablets. Film-coated azathioprine tablets should not be divided and, provided the coating is intact, no additional precautions are required when handling them. Disposal A

Who manufactures Azathioprine VIS?

Zakłady Chemiczno-Farmaceutyczne "VIS" Sp. z o.o. (Polska)

What ATC class does Azathioprine VIS belong to?

Azathioprine VIS: ATC L04AX01. ATC is the WHO Anatomical Therapeutic Chemical classification — it groups drugs by organ system and pharmacological mechanism.

Azathioprine VIS

This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.

Azathioprine VIS — Description, Dosage, Side Effects | PillsCard

Pharmacotherapeutic group: Antineoplastic and Immunomodulating agents, Immunosuppressants, Other immunosuppressants ATC code: L04AX01 Azathioprine is an imidazole derivative of 6-mercaptopurine (6-MP).‍‍‍‍‍‍‍‍‍‍‍‍‍ It is rapidly broken down in vivo into 6-MP and a methylnitroimidazole moiety. The 6-MP readily crosses cell membranes and is converted intracellularly into a number of purine thioanalogues, which include the main active nucleotide, thioinosinic acid. The rate of conversion varies from one person to another. Nucleotides do not traverse cell membranes and therefore do not circulate in body fluids. Irrespective of whether it is given directly or is derived in vivo from azathioprine, 6-MP is eliminated mainly as the inactive oxidised metabolite thiouric acid. This oxidation is brought about by xanthine oxidase, an enzyme that is inhibited by allopurinol. The activity of the methylnitroimidazole moiety has not been defined clearly. However, in several systems it appears to modify the activity of azathioprine as compared with that of 6-MP. Determination of plasma concentrations of azathioprine or 6-MP have no prognostic value as regards effectiveness or toxicity of these compounds. While the precise modes of action remain to be elucidated, some suggested mechanisms include: 1. The release of 6-MP which acts as a purine antimetabolite. 2. The possible blockade of -SH groups by alkylation. 3. The inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation of cells involved in determination and amplification of the immune response. 4. Damage to deoxyribonucleic acid (DNA) through incorporation of purine thio-analogues. Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Azathioprine appears to be well absorbed from the upper gastro-intestinal tract. Studies in mice with [ 35 S]-azathioprine showed no unusually large concentration in any particular tissue, and there was very little [ 35 S]-label found in brain. Plasma levels of azathioprine and 6-mercaptopurine do not correlate well with the therapeutic efficacy or toxicity of azathioprine.

Azathioprine VIS

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