This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.
Rx
Adtralza
300 mg, Roztwór do wstrzykiwań we wstrzykiwaczu
INN: Tralokinumabum
Data updated: 2026-04-13
Available in:
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Form
Roztwór do wstrzykiwań we wstrzykiwaczu
Dosage
300 mg
Route
podskórnie
Storage
—
About This Product
User Reviews
Reviews reflect personal experiences and are not medical advice. Always consult your doctor.
Manufacturer
LEO Pharma A/S (Dania)
Composition
Tralokinumabum 300 mg
ATC Code
D11AH07
Source
URPL
Tralokinumab is a fully human IgG4 monoclonal antibody that specifically binds interleukin-13 (IL-13), a type 2 cytokine, and blocks its interaction with IL-13 receptors. The drug neutralises the biological activity of IL-13 by inhibiting its binding to the IL-13Rα1/IL-4Rα receptor complex.
Interleukin-13 plays a key role in the pathogenesis of atopic dermatitis — it enhances inflammation, impairs epidermal barrier function by affecting the expression of structural proteins (including filaggrin), and promotes pruritus and chronic persistence of skin lesions.
Inhibition of the IL-13 pathway by tralokinumab leads to reduced activity of numerous inflammatory mediators, thereby alleviating the symptoms of atopic dermatitis.
The bioavailability of tralokinumab following subcutaneous administration is approximately 60%.
Tralokinumab is a protein and is therefore expected to be degraded into smaller peptides and subsequently into amino acids, which are used by the body as building blocks.
The elimination half-life of tralokinumab is approximately 22 days.
⚠️ Warnings
During treatment with tralokinumab, there is a risk of conjunctivitis, which should be treated with standard therapy. If the inflammation does not resolve following medication, the patient should be referred for an ophthalmological examination.
Before initiating therapy, it is recommended that patients are brought up to date with their vaccination schedule. Particular attention should be paid to vaccinations using live and attenuated microorganisms. There are no studies confirming the safety and efficacy of such vaccines during concomitant use of tralokinumab.
Patients with confirmed parasitic infections were excluded from clinical trials. Due to the immunosuppressive action of tralokinumab, it is recommended that individuals with confirmed parasitic infections receive treatment before initiating tralokinumab therapy.
During treatment with tralokinumab, hypersensitivity reactions posing a risk to the patient may occur. If symptoms of hypersensitivity appear, administration of the drug should be immediately discontinued and appropriate supportive therapy initiated.