GARDASIL [Quadrivalent Human Papillomavirus (Types 6,11,16,18) Recombinant Vaccine]

right hemisphere of cerebellumspinal gangliatrigeminal ganglioncerebellar vermissural nerveparaflocculus of cerebellumolfactory bulbBrodmann area 10right frontal lobesuperior frontal gyrus medial dorsal nucleussuperior cervical ganglionsubiculumlateral geniculate nucleusbarrel cortexmedial geniculate nucleusventromedial nucleusparaventricular nucleus of hypothalamusdorsomedial hypothalamic nucleusnucleus accumbens protein bindingprotein domain specific bindingaxon guidance receptor activity cell projectiongrowth conemembranefocal adhesioncell surfaceintegral component of membraneaxonal growth coneplasma membraneaxondendritesomaextracellular matrixcollagen-containing extracellular matrix multicellular organism developmentnervous system developmentpositive regulation of axon extensioncell differentiationleukocyte migrationcell adhesionchemotaxiscell-matrix adhesionaxon guidancecell migrationneuron projection developmentsynapse organizationaxon developmenthomophilic cell adhesion via plasma membrane adhesion molecules 3897 16728 ENSG00000198910 ENSMUSG00000031391 P32004 P11627 NM_024003NM_000425NM_001143963NM_001278116 NM_008478NM_001374694 NP_000416NP_001137435NP_001265045NP_076493 n/a L1, also known asL1CAM, is atransmembrane proteinmember of theL1 protein family, encoded by theL1CAMgene. This protein, of 200 to 220 kDa, is a neuronalcell adhesion moleculewith a strong implication in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation.It also plays a key role in treatment-resistant cancers due to its function. It was first identified in 1984 by M. Schachner who found the protein in post-mitotic miceneurons. Mutations in the L1 protein are the cause ofL1 syndrome, sometimes known by the acronym CRASH(corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus).