Colchicum dispert

Any unused medicinal product or waste material should be disposed of in accordance with local requirements. For patients where oral administration of a tablet is not possible, administration can be achieved by tablet solubilisation, and subsequent administration as an oral dispersion, or via a nasogastric tube or a percutaneous endoscopic gastrostomy (PEG) tube.​‍​​​​​‍​‍‍‍‍​‍‍ Such dispersions should be administered as suggested in the following recommendations. For dosage see section 4.2. Administration as an oral dispersion: The dose may be dispersed in a medicines cup containing between 10 ml – 30 ml of water. Add a single tablet to the volume of water and stir for five seconds using a suitable stirring device e.g. spoon. Allow to stand for about 2 minutes and stir for five seconds, and 5 minutes after tablet addition, stir for a further five seconds and administer the entire volume orally immediately. To ensure complete administration of the dose, the cup should be rinsed with a further quantity of water, 10 ml – 30 ml, and administered orally. Alternatively, the dose may be administered via a 5 ml oral dosing syringe (enteral medicines dispenser). Remove the plunger and insert one tablet into the device. Replace the plunger and depress until in contact with the tablet. Draw up 5 ml of water into the device and expel any residual air. Disperse the tablet by rotation of the dispenser in a vertical axis, five times, allow to stand for 5 minutes, repeat the five rotations, allow again to stand for five minutes, repeat the five rotations. Administer the required dose immediately. To ensure complete dosage administration, a further 5 ml quantity of water should be drawn up into the dosing syringe and administered immediately. Administration via a nasogastric or percutaneous endoscopic gastrostomy (PEG) Tube: Tubes made of polyurethane, polyvinylchloride, or silicone are suitable for use. There is no data available on tubes made of latex. Therefore, latex tubes should not be used. Use a 60 ml syringe and remove the plunger, insert one tablet in the syringe barrel, and replace the plunger, depressing until just clear of tablet. Draw 30 ml of water into the syringe, and manually shake for 30 seconds. Shake for another 30 seconds after 5 minutes, 10 minutes, and 15 minutes post water draw up. Administer the dispersed dose, via nasogastric or PEG tube immediately after preparation. Following administration, the dosing syringe should be disconnected and flushed with a further quantity, 10 ml – 30 ml of water, which should also be administered via tube to ensure complete dosage administration. In cases of fluid restriction, the initial volume for dispersion may be reduced to a minimum of 10 ml.