This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.
Description, Dosage, Side Effects, Contraindications. Data from EMA, URPL, openFDA and other regulatory sources.
| Ondansetron | Metoclopramide | |
|---|---|---|
| Active Substances | ONDANSETRON | METOCLOPRAMIDE HYDROCHLORIDE |
| ATC Code | A04AA01 | A03FA01 |
| Form | — | INJECTABLE |
| Dosage | — | EQ 5MG BASE/ML |
| Route | — | INJECTION |
| Manufacturer | JAMP PHARMA CORPORATION | AVET LIFESCIENCES LTD |
| Indications | This medication is a 5-HT3 receptor antagonist, prescribed for nausea and vomiting caused by cancer chemotherapy, radiation therapy and surgery. It blocks serotonin receptors in the vomiting center and on nerves supplying the digestive system. | This medication is a gastrointestinal stimulant and antinauseant, prescribed for heartburn and esophagitis due to GERD and for treating patients who have gastroparesis (partial paralysis of the stomach) and prevention of nausea and vomiting associated with cancer chemotherapy. |
| Side Effects |
Ondansetron (INN: ONDANSETRON, ATC A04AA01) and Metoclopramide (INN: METOCLOPRAMIDE HYDROCHLORIDE, ATC A03FA01) differ in active substance, indications, and safety profile. The table above summarizes the clinical differences from regulatory documents.
Combination safety depends on mechanisms and your health profile. Use our interactions checker and always consult your doctor or pharmacist before combining medications.
Both drugs are approved when used per label. Safety is patient-specific — the better choice depends on your condition, other medications, allergies, and comorbidities. Consult a healthcare professional for personalized advice.
This information is for educational purposes only. It is not intended as medical advice. Always consult a qualified healthcare professional.
| Heart - Chest pain, fast heart rate. Central Nervous System - Headache, seizures, dizziness. Skin - Rash. Gastrointestinal - Dry mouth, constipation, abdominal pain. Metabolic - Low potassium in blood, increased level of liver enzymes. Respiratory - Asthma. Genitourinary - Gynecological disorder, urinary retention. Miscellaneous - Fever, anaphylaxis, weakness. |
| Heart - Acute heart failure, slow heart rate, fluid retention, high blood pressure, low blood pressure and fast heart rate. Central Nervous System - Sedation, dizziness, restlessness, involuntary body movements, spasms, depression, malignant neuroleptic syndrome (condition where patient experiences rigidity, decreased consciousness, fever and fluctuating blood pressure and heart rate – may be fatal). Gastrointestinal - Bowel disturbances, primarily diarrhea and nausea. Skin - Transient flushing of face or upper body with high IV doses. Hormone - Galactorrhea ( spontaneous flow of milk from the breast), breast enlargement in men and increase in serum prolactin. Genitourinary - Absence of a menstrual period, elevation of aldosterone, fluid retention, impotence, incontinence and urinary frequency. Liver - Liver toxicity (rare). Blood - Decrease in white blood cells and changes in hemoglobin. Hypersensitivity - Rapid swelling of dermis, including glossal or laryngeal edema (rare), rash and itching. Miscellaneous - Visual disturbances. |
| Warnings | •It may affect heart rhythm, cause severe liver impairment. Caution needed when used in cardiac diseases, patients who are on medications that can prolong QT or patients with electrolyte abnormalities, during pregnancy and breastfeeding. • It may mask progressive ileus and/or gastric distension. | •Caution needed for children, elderly, patients with history of liver or kidney disease, porphyria (group of inherited or acquired disorders of certain enzymes), epilepsy, Parkinson's disease, diabetes, history of depression. It may cause dizziness. Do not drive a car or operate machinery until you know how this medication affects you. Do not drink alcohol or use medicines that may cause drowsiness. Do not take more than the recommended dose or use this medication for longer than 12 weeks without checking with your doctor. Avoid prolong usage of this medication, otherwise it may lead to involuntary movements. |
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